Daptomycin for the treatment of osteomyelitis associated with a diabetic foot ulcer.

 This report describes a case of Staphylococcus aureus osteomyelitis associated with a chronic foot ulcer that was successfully treated with surgical debridement and 6 weeks of daptomycin therapy. Daptomycin was chosen because of its excellent activity against the causative organism and the patient's history of penicillin allergy. Its tolerability and ease of administration also facilitated long-term outpatient management. The present case provides further evidence that supports consideration of daptomycin as a treatment for S aureus osteomyelitis, especially in light of reports of methicillin-sensitive S aureus (MSSA) infection recurrence after vancomycin use and safety issues surrounding long-term use of linezolid.